The design of coastal oil and gasoline tanks along with interconnected onshore and offshore pipeline in an area that is characterized by very loose to loose granular and very soft to soft clayey soils, high water table and moderate or high seismicity will be much more demanding and challenging, since various issues are directly or indirectly associated to (a) settlements over time and (b) a potential earthquake. The current paper aims to illustrate the following main topics: (a) estimation-calculation of settlements and their consolidation time and (b) earthquake-related geohazard and soil-structure interaction that have to be coped with for the proper design of tanks’ foundation as well as pipelines in a coastal area at Northern Greece. As a consequence, the main earthquake-related geohazards that are present in the study area are briefly presented, such as seismic wave loading, active-fault rupture, and soil liquefaction phenomena. Emphasis is also given to the numerical simulation of the static and dynamic interaction between the pipeline and the surrounding soil as well as the foundation type and the soil underneath. Since foundation soil will lose its shear strength during an earthquake, specific mitigation measures are proposed. These measures may also be adopted in the case of excessive pipeline distress