Since the year 1996; a 100 cubic meter per hour of crude oil is pumped, in western desert at Egypt through (152.4 mm x 55 km) transportation pipeline against Difference in Elevation (DE) as 200 m, using two identical centrifugal pumps connected in series working at best Overall Pumping Efficiency (OPE), a 1.34 kilo Horsepower diesel engine is used to generate necessary power for motors run the two pumps. OPE was 63%. By long operation time, there was remarkable increase in the diesel demand as fuel needed for achievement of pumping operation, referred to: 1- Aging of the pumps resulting in reduced OPE as 50%, this aging is treated by frequent routine maintenance. 2- Aging of the transportation pipeline, resulting in increased Hydraulic Friction Losses (HFL), which was reduced by 52% by injection of Drag Reducing Agent (DRA) with proper doses. This paper presents engineering and economic studies comparing consumption of diesel fuel through three ways: -1) Replacing one of the two pumps with a new one of updated OPE or continue with schedule of routine and preventive maintenance to keep the reduced OPE without further degradation. -2) Replacing the existing pipeline with a new one of less internal wall roughness or looping part of this pipeline to minimize HFL. -3) Using DRA to achieve reduction in HFL. Diesel consumption in each of the three ways is calculated, to select from which the most economic way to proceed with. This paper contributes for designed software programs applied in the three comparison ways including necessary hydraulic models for deducing impact of DRA in addition to making use of observing changing pump performance charts over time (flow rate versus developed head, loading of driving motor and derived OPE). Obtained results by the three ways can be applied for other similar situations.